Baseline incidence of meningitis, malaria, mortality and other health outcomes in infants and young sub-Saharan African children prior to the introduction of the RTS,S/AS01_E malaria vaccine.

ABSTRACT:

Background

The lack of background disease incidence rates in sub-Saharan countries where the RTS,S/AS01_E malaria vaccine is being implemented may hamper the assessment of vaccine safety and effectiveness. This study aimed to document baseline incidence rates of meningitis, malaria, mortality, and other health outcomes prior to vaccine introduction through the Malaria Vaccine Implementation Programme.

Methods

An ongoing disease surveillance study is combining prospective cohort event monitoring and hospital-based disease surveillance in three study sites in Ghana and Kenya. An interim analysis was performed on the prospective cohort in which children were enrolled in two age-groups (the 5 to 17 months or 6 to 12 weeks age-group), capturing data in the framework of

SUBMITTER: RTS,S Epidemiology EPI-MAL-002 Study Group 

PROVIDER: S-EPMC8073890 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature