Distinct diagnostic and prognostic values of Glypicans gene expression in patients with hepatocellular carcinoma.

ABSTRACT:

Backgroud

In our current work, we aimed to investigate the expressions of glypican (GPC) family genes at the mRNA level and assess their prognostic significances in patients with hepatocellular carcinoma (HCC).

Methods

The pathological roles of GPC family genes were examined using bioinformatics analysis. The diagnostic values of GPC genes were explored with the Gene Expression Profiling Interactive Analysis. Moreover, the mRNA expression and prognostic values of GPC genes were assessed via the KM plotter database.

Results

Our data showed that the expression of GPC-3 was dramatically increased in the liver tumor tissue. Moreover, the expressions of the other five GPC family members were not significantly different between the tumor and normal liver tissues (P > 0.05).

SUBMITTER: Wang JY 

PROVIDER: S-EPMC8073913 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature