EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer.
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ABSTRACT:
SUBMITTER: Kim SH
PROVIDER: S-EPMC8073943 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer.
Kim Song-Hee SH Kang Byung-Chul BC Seong Daseul D Lee Won-Hyeok WH An Jae-Hee JH Je Hyoung-Uk HU Cha Hee-Jeong HJ Chang Hyo-Won HW Kim Sang-Yoon SY Kim Seong-Who SW Han Myung-Woul MW
Biomolecules 20210418 4
EPHA3, a member of the EPH family, is overexpressed in various cancers. We demonstrated previously that EPHA3 is associated with radiation resistance in head and neck cancer via the PTEN/Akt/EMT pathway; the inhibition of EPHA3 significantly enhances the efficacy of radiotherapy in vitro and in vivo. In this study, we investigated the mechanisms of PTEN regulation through EPHA3-related signaling. Increased DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2) levels, along with ...[more]
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