Structural Basis for the C-Terminal Domain of Mycobacterium tuberculosis Ribosome Maturation Factor RimM to Bind Ribosomal Protein S19.

ABSTRACT: Multidrug-resistant tuberculosis (TB) is a serious threat to public health, calling for the development of new anti-TB drugs. Chaperon protein RimM, involved in the assembly of ribosomal protein S19 into 30S ribosomal subunit during ribosome maturation, is a potential drug target for TB treatment. The C-terminal domain (CTD) of RimM is primarily responsible for binding S19. However, both the CTD structure of RimM from Mycobacterium tuberculosis (MtbRimM_CTD) and the molecular mechanisms underlying MtbRimM_CTD binding S19 remain elusive. Here, we report the solution structure, dynamics features of MtbRimM_CTD, and its interaction with S19. MtbRimM_CTD has a rigid hydrophobic core comprised of a relatively conservativ

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8073977 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature