Set-based genetic association and interaction tests for survival outcomes based on weighted V statistics.

ABSTRACT: With advancements in high-throughout technologies, studies have been conducted to investigate the role of massive genetic variants in human diseases. While set-based tests have been developed for binary and continuous disease outcomes, there are few computationally efficient set-based tests available for time-to-event outcomes. To facilitate the genetic association and interaction analyses of time-to-event outcomes, We develop a suite of multivariant tests based on weighted V statistics with or without considering potential genetic heterogeneity. In addition to the computation efficiency and nice asymptotic properties, all the new tests can deal with left truncation and competing risks in the survival data, and adjust for covariates. Simulation studies show that the new tests run faster, a

SUBMITTER: Li C 

PROVIDER: S-EPMC8074363 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature