Transient cell stiffening triggered by magnetic nanoparticle exposure.

ABSTRACT:

Background

The interactions between nanoparticles and the biological environment have long been studied, with toxicological assays being the most common experimental route. In parallel, recent growing evidence has brought into light the important role that cell mechanics play in numerous cell biological processes. However, despite the prevalence of nanotechnology applications in biology, and in particular the increased use of magnetic nanoparticles for cell therapy and imaging, the impact of nanoparticles on the cells' mechanical properties remains poorly understood.

Results

Here, we used a parallel plate rheometer to measure the impact of magnetic nanoparticles on the viscoelastic modulus G*(f) of individual cells. We show how the active uptake of nanoparticles translates i

SUBMITTER: Perez JE 

PROVIDER: S-EPMC8074464 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature