Tunable electroconductive decellularized extracellular matrix hydrogels for engineering human cardiac microphysiological systems.

ABSTRACT: Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs) offer tremendous potential when used to engineer human tissues for drug screening and disease modeling; however, phenotypic immaturity reduces assay reliability when translating in vitro results to clinical studies. To address this, we have developed hybrid hydrogels comprised of decellularized porcine myocardial extracellular matrix (dECM) and reduced graphene oxide (rGO) to provide a more instructive microenvironment for proper cell and tissue development. A tissue-specific protein profile was preserved post-decellularization, and through the modulation of rGO content and degree of reduction, the mechanical and electrical properties of the hydrogels could be tuned. Engineered heart tissues (EHTs) generated u

SUBMITTER: Tsui JH 

PROVIDER: S-EPMC8074529 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature