The Role of Microbiome and Virome in Idiopathic Pulmonary Fibrosis.

ABSTRACT: The interest in the lung microbiome and virome and their contribution to the pathogenesis, perpetuation and progression of idiopathic pulmonary fibrosis (IPF) has been increasing during the last decade. The utilization of high-throughput sequencing to detect microbial and/or viral genetic material in bronchoalveolar lavage fluid or lung tissue samples has amplified the ability to identify and quantify specific microbial and viral populations. In stable IPF, higher microbial burden is associated with worse prognosis but no specific microbe has been identified to contribute to this. Additionally, no causative relation has been established. Regarding viral infections, although in the past they have been associated with IPF, causation has not been proved. Although in the past the diagnosis of

SUBMITTER: Ntolios P 

PROVIDER: S-EPMC8074588 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature