COVID-19: captures iron and generates reactive oxygen species to damage the human immune system.

ABSTRACT: Currently, the novel coronavirus pneumonia has been widespread globally, and there is no specific medicine. In response to the emergency, we employed bioinformatics methods to investigate the virus's pathogenic mechanism, finding possible control methods. We speculated in previous studies that E protein was associated with viral infectivity. The present study adopted the domain search techniques to analyse the E protein. According to the results, the E protein could bind iron or haem. The iron and haem bound by the E protein came from the attacked haemoglobin and phagocytes. When E protein was attached to haem, it synthesised oxygen and water into superoxide anions, hydrogen peroxide and hydroxyl radicals. When the iron-bound E protein and the haem-bound E protein worked together, they con

SUBMITTER: Wenzhong L 

PROVIDER: S-EPMC8074649 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature