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Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer.

ABSTRACT: Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound 8d inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with improved selectivity towards cancer cells. The antiproliferative activity of 8d is achieved through triggering apoptotic cell death.

SUBMITTER: Fu B

PROVIDER: S-EPMC8074679 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer.

Fu Boqiao B Li Yingjie Y Peng Shaoyong S Wang Xiaolin X Hu Jingying J Lv Long L Xia Caifen C Lu Dai D Qin Caiqin C

Royal Society open science 20210224 2

Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound <b>8d</b> inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with improved selectivity towards cancer cells. The antiproliferative activity of <b>8d</b> is achieved through triggering apoptotic cell death. ...[more]

PMID: 33972860

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