Crohn's Disease Increases the Mesothelial Properties of Adipocyte Progenitors in the Creeping Fat.

ABSTRACT: Our understanding of the interplay between human adipose tissue and the immune system is limited. The mesothelium, an immunologically active structure, emerged as a source of visceral adipose tissue. After investigating the mesothelial properties of human visceral and subcutaneous adipose tissue and their progenitors, we explored whether the dysfunctional obese and Crohn's disease environments influence the mesothelial/mesenchymal properties of their adipocyte precursors, as well as their ability to mount an immune response. Using a tandem transcriptomic/proteomic approach, we evaluated the mesothelial and mesenchymal expression profiles in adipose tissue, both in subjects covering a wide range of body-mass indexes and in Crohn's disease patients. We also isolated adipose tissue precursors

SUBMITTER: Madeira A 

PROVIDER: S-EPMC8074767 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature