A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder.

ABSTRACT:

Objectives

Frustration is associated with impaired attention, heightened arousal, and greater unhappiness in youths with bipolar disorder (BD) vs healthy volunteers (HV). Little is known about functional activation and connectivity in the brain of BD youths in response to frustration. This exploratory study compared BD youths and HV on attentional abilities, self-reported affect, and functional activation and connectivity during a frustrating attention task.

Methods

Twenty BD (M_age  = 15.86) and 20 HV (M_age  = 15.55) youths completed an fMRI paradigm that differentiated neural responses during processing of frustrating feedback from neural responses during attention orienting following frustrating feedback. We examined group differences in (a) functiona

SUBMITTER: Ross AJ 

PROVIDER: S-EPMC8074834 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature