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The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids.

ABSTRACT: Binding behaviours between cyclopentanocucurbit[6]uril (CyP₆Q[6]) and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance spectroscopy and isothermal titration calorimetry. The results showed that CyP₆Q[6] forms a 1 : 2 inclusion complex with glycine, but 1 : 1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP₆Q[6], only the alkyl chains of leucine and lysine can enter this cavity. Interestingly, leucine can adopt two different self-assembly modes upon its interaction with cucurbituril, depending on the external conditions, whereas glycine and lysine do not exhibit such behaviour.

SUBMITTER: Cheng S

PROVIDER: S-EPMC8074881 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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The binding behaviours between cyclopentanocucurbit[6]uril and three amino acids.

Cheng Siyuan S Zhao Weiwei W Yang Xinan X Meng Ye Y Wei Liantong L Tao Zhu Z Ma Peihua P

Royal Society open science 20210331 3

Binding behaviours between cyclopentanocucurbit[6]uril (CyP6Q[6]) and three amino acids have been investigated by means of X-ray crystallography, proton nuclear magnetic resonance spectroscopy and isothermal titration calorimetry. The results showed that CyP6Q[6] forms a 1 : 2 inclusion complex with glycine, but 1 : 1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP6Q[6], only the alkyl chai ...[more]

PMID: 33959363

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