Quantifying the risk of vector-borne disease transmission attributable to genetically modified vectors.

ABSTRACT: The relative risk of disease transmission caused by the potential release of transgenic vectors, such as through sterile insect technique or gene drive systems, is assessed with comparison with wild-type vectors. The probabilistic risk framework is demonstrated with an assessment of the relative risk of lymphatic filariasis, malaria and o'nyong'nyong arbovirus transmission by mosquito vectors to human hosts given a released transgenic strain of Anopheles coluzzii carrying a dominant sterile male gene construct. Harm is quantified by a logarithmic loss function that depends on the causal risk ratio, which is a quotient of basic reproduction numbers derived from mathematical models of disease transmission. The basic reproduction numbers are predicted to depend on the number of generat

SUBMITTER: Hosack GR 

PROVIDER: S-EPMC8074930 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature