Graph-structured populations and the Hill-Robertson effect.

ABSTRACT: The Hill-Robertson effect describes how, in a finite panmictic diploid population, selection at one diallelic locus reduces the fixation probability of a selectively favoured allele at a second, linked diallelic locus. Here we investigate the influence of population structure on the Hill-Robertson effect in a population of size N. We model population structure as a network by assuming that individuals occupy nodes on a graph connected by edges that link members who can reproduce with each other. Three regular networks (fully connected, ring and torus), two forms of scale-free network and a star are examined. We find that (i) the effect of population structure on the probability of fixation of the favourable allele is invariant for regular structures, but on some scale-free networks

SUBMITTER: Whigham PA 

PROVIDER: S-EPMC8074956 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature