Arginine vasopressin receptor 2 activation promotes microvascular permeability in sepsis.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) sepsis is a severe condition associated with vascular leakage and poor prognosis. The hemodynamic management of sepsis targets hypotension, but there is no specific treatment available for vascular leakage. Arginine vasopressin (AVP) has been used in sepsis to promote vasoconstriction by activating AVP receptor 1 (V₁R). However, recent evidence suggests that increased fluid retention may be associated with the AVP receptor 2 (V₂R) activation worsening the outcome of sepsis. Hence, we hypothesized that the inhibition of V₂R activation ameliorates the severity of microvascular hyperpermeability during sepsis. The hypothesis was tested using a well-characterized and clinically relevant ovine model of MRSA pneu

SUBMITTER: Lopez E 

PROVIDER: S-EPMC8075069 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature