Dysregulated functional brain connectivity in response to acute social-evaluative stress in adolescents with PTSD symptoms.

ABSTRACT: Background: Posttraumatic stress disorder (PTSD) is associated with dysregulated neural, cortisol, and cardiac stress reactivity and recovery. This understanding is predominantly based on studies in adults applying emotional-cognitive and trauma-related stimuli inducing negative emotions or perceived threat. Despite large numbers of adolescents with PTSD, few studies are available on neurobiological stress reactivity in this population. Moreover, no previous studies investigated neural reactivity to social-evaluative stress. Objective: To investigate functional brain connectivity, cortisol and cardiac reactivity to acute social-evaluative stress, and additional cortisol measures in trauma-exposed adolescents with and without high PTSD symptoms. Method: A speech prepara

SUBMITTER: Hilberdink CE 

PROVIDER: S-EPMC8075091 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature