Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial.

ABSTRACT:

Objective

This study was undertaken to describe patterns of benzodiazepine use as first-line treatment of status epilepticus (SE) and test the association of benzodiazepine doses with response to second-line agents in patients enrolled in the Established Status Epilepticus Treatment Trial (ESETT).

Methods

Patients refractory to an adequate dose of benzodiazepines for the treatment of SE were enrolled in ESETT. Choice of benzodiazepine, doses given prior to administration of second-line agent, route of administration, setting, and patient weight were characterized. These were compared with guideline-recommended dosing. Logistic regression was used to determine the association of the first dose of benzodiazepine and the cumulative benzodiazepine dose with the response to secon

SUBMITTER: Sathe AG 

PROVIDER: S-EPMC8075113 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature