Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARγ Pathway in White Adipose.

ABSTRACT: Obesity is characterized by excessive fat accumulation and associated with glucose and lipid metabolism disorders. Crtc1, a transcription cofactor regulating CREB activity, has been involved in the pathogenesis of metabolic syndrome; however, the underlying mechanism remains under debate. Here we generated a Crtc1^-/- mouse line using the CRISPR/Cas9 system. Under normal feeding conditions, Crtc1^-/- mice exhibited an obese phenotype resultant from the abnormal expansion of the white adipocytes. The development of obesity in Crtc1^-/- mice is independent of alterations in food intake or energy expenditure. Moreover, Crtc1^-/- mice were more prone to insulin resistance and dyslipidemia, as evidenced by higher levels of plasma glucose, insulin and FABP

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8075410 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature