Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes.
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ABSTRACT:
SUBMITTER: Yingxuan E
PROVIDER: S-EPMC8075527 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes.
Yingxuan Eng E Yao Xiaohui X Liu Kefei K Risacher Shannon L SL Saykin Andrew J AJ Long Qi Q Zhao Yize Y Shen Li L
AMIA ... Annual Symposium proceedings. AMIA Symposium 20200101
Mediation models have been employed in the study of brain disorders to detect the underlying mechanisms between genetic variants and diagnostic outcomes implicitly mediated by intermediate imaging biomarkers. However, the statistical power is influenced by the modest effects of individual genetic variants on both diagnostic and imaging phenotypes and the limited sample sizes ofimaging genetic cohorts. In this study, we propose a polygenic mediation analysis that comprises a polygenic risk score ...[more]
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