Role of the DNA damage response in prostate cancer formation, progression and treatment.

ABSTRACT:

Background

Clinical and preclinical studies have revealed that alterations in DNA damage response (DDR) pathways may play an important role in prostate cancer (PCa) etiology and progression. These alterations can influence PCa responses to radiotherapy and anti-androgen treatment. The identification of DNA repair gene aberrations in PCa has driven the interest for further evaluation whether these genetic changes may serve as biomarkers for patient stratification.

Methods

In this review, we summarize the current knowledge on DDR alterations in PCa, their potential impact on clinical interventions and prospects for improved management of PCa. We particularly focus on the influence of DDR gene mutations on PCa initiation and progression and describe the underlying mechanisms.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8076026 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature