Whole-brain amide CEST imaging at 3T with a steady-state radial MRI acquisition.

ABSTRACT:

Purpose

To develop a steady-state saturation with radial readout chemical exchange saturation transfer (starCEST) for acquiring CEST images at 3 Tesla (T). The polynomial Lorentzian line-shape fitting approach was further developed for extracting amideCEST intensities at this field.

Method

StarCEST MRI using periodically rotated overlapping parallel lines with enhanced reconstruction-based spatial sampling was implemented to acquire Z-spectra that are robust to brain motion. Multi-linear singular value decomposition postprocessing was applied to enhance the CEST SNR. The egg white phantom studies were performed at 3T to reveal the contributions to the 3.5 ppm CEST signal. Based on the phantom validation, the amideCEST peak was quantified using the polynomial Lorentzian line-

SUBMITTER: Sui R 

PROVIDER: S-EPMC8076068 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature