Antihormone treatment differentially regulates PSA secretion, PSMA expression and ⁶⁸Ga-PSMA uptake in LNCaP cells.

ABSTRACT:

Background

In recent years, a variety of innovative therapeutics for castration-resistant prostate cancer have been developed, including novel anti-androgenic drugs, such as abiraterone or VPC-13566. Therapeutic monitoring of these pharmaceuticals is performed either by measuring PSA levels in serum or by imaging. PET using PSMA ligands labeled with Fluor-18 or Gallium-68 is the most sensitive and specific imaging modality for detection of metastases in advanced prostate cancer. To date, it remains unclear how PSMA expression is modulated by anti-hormonal treatment and how it correlates with PSA secretion.

Methods

We analyzed modulation of PSMA-mRNA and protein expression, ⁶⁸Ga-PSMA uptake and regulation of PSA secretion by abiraterone or VPC-13566 in LNCaP cells

SUBMITTER: Mathy CS 

PROVIDER: S-EPMC8076114 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature