Magnetic probe-based microrheology reveals local softening and stiffening of 3D collagen matrices by fibroblasts.

ABSTRACT: Changes in extracellular matrix stiffness impact a variety of biological processes including cancer progression. However, cells also actively remodel the matrices they interact with, dynamically altering the matrix mechanics they respond to. Further, cells not only react to matrix stiffness, but also have a distinct reaction to matrix viscoelasticity. The impact of cell-driven matrix remodeling on matrix stiffness and viscoelasticity at the microscale remains unclear, as existing methods to measure mechanics are largely at the bulk scale or probe only the surface of matrices, and focus on stiffness. Yet, establishing the impact of the matrix remodeling at the microscale is crucial to obtaining an understanding of mechanotransduction in biological matrices, and biological matrices are not j

SUBMITTER: Pokki J 

PROVIDER: S-EPMC8076128 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature