Gene network and biological pathways associated with susceptibility to differentiated thyroid carcinoma.

ABSTRACT: Variants identified in earlier genome-wide association studies (GWAS) on differentiated thyroid carcinoma (DTC) explain about 10% of the overall estimated genetic contribution and could not provide complete insights into biological mechanisms involved in DTC susceptibility. Integrating systems biology information from model organisms, genome-wide expression data from tumor and matched normal tissue and GWAS data could help identifying DTC-associated genes, and pathways or functional networks in which they are involved. We performed data mining of GWAS data of the EPITHYR consortium (1551 cases and 1957 controls) using various pathways and protein-protein interaction (PPI) annotation databases and gene expression data from The Cancer Genome Atlas. We identified eight DTC-associated genes at

SUBMITTER: Kulkarni O 

PROVIDER: S-EPMC8076215 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature