Survival from breast cancer in women with a BRCA2 mutation by treatment.

ABSTRACT:

Background

The impact of various breast-cancer treatments on patients with a BRCA2 mutation has not been studied. We sought to estimate the impact of bilateral oophorectomy and other treatments on breast cancer-specific survival among patients with a germline BRCA2 mutation.

Methods

We identified 664 women with stage I-III breast cancer and a BRCA2 mutation by combining five different datasets (retrospective and prospective). Subjects were followed for 7.2 years from diagnosis to death from breast cancer. Tumour characteristics and cancer treatments were patient-reported and derived from medical records. Predictors of survival were determined using Cox proportional hazard models, adjusted for other treatments and for prognostic features.

Results

The 10-year breast-can

SUBMITTER: Evans DG 

PROVIDER: S-EPMC8076275 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature