Enhanced generation of influenza-specific tissue resident memory CD8 T cells in NK-depleted mice.

ABSTRACT: Natural Killer (NK) cells are among the first effectors to directly contact influenza and influenza-infected cells and their activation affects not only their intrinsic functions, but also subsequent CD8⁺ T cell responses. We utilized a NK cell depletion model to interrogate the contribution of NK cells to the development of anti-influenza CD8⁺ T cell memory. NK cell ablation increased the number of influenza-specific memory CD8⁺ T cells in the respiratory tract and lung-draining lymph node. Interestingly, animals depleted of NK cells during primary influenza infection were protected as well as their NK-intact counterparts despite significantly fewer reactivated CD8⁺ T cells infiltrating the respiratory tract after lethal, heterosubtypic challeng

SUBMITTER: Rose DL 

PROVIDER: S-EPMC8076325 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature