Father absence, age at menarche, and genetic confounding: A replication and extension using a polygenic score.

ABSTRACT: Father absence has a small but robust association with earlier age at menarche (AAM), likely reflecting both genetic confounding and an environmental influence on life history strategy development. Studies that have attempted to disambiguate genetic versus environmental contributions to this association have shown conflicting findings, though genomic-based studies have begun to establish the role of gene-environment interplay in the father absence/AAM literature. The purpose of this study was to replicate and extend prior genomic work using the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective longitudinal cohort study (N = 2,685), by (a) testing if an AAM polygenic score (PGS) could account for the father absence/AAM association, (b) replicating G×E research on lin-2

SUBMITTER: Schlomer GL 

PROVIDER: S-EPMC8076333 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature