A multi-omic analysis of the dorsal striatum in an animal model of divergent genetic risk for alcohol use disorder.

ABSTRACT: The development of selectively bred high and low alcohol-preferring mice (HAP and LAP, respectively) has allowed for an assessment of the polygenetic risk for pathological alcohol consumption and phenotypes associated with alcohol use disorder (AUD). Accumulating evidence indicates that the dorsal striatum (DS) is a central node in the neurocircuitry underlying addictive processes. Therefore, knowledge of differential gene, protein, and phosphorylated protein expression in the DS of HAP and LAP mice may foster new insights into how aberrant DS functioning may contribute to AUD-related phenotypes. To begin to elucidate these basal differences, a complementary and integrated analysis of DS tissue from alcohol-naïve male and female HAP and LAP mice was performed using RNA sequencing, quantita

SUBMITTER: Grecco GG 

PROVIDER: S-EPMC8076345 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature