Warranty Period of a Calcium Score of Zero: Comprehensive Analysis From MESA.

ABSTRACT:

Objectives

This study sought to quantify and model conversion of a normal coronary artery calcium (CAC) scan to an abnormal CAC scan.

Background

Although the absence of CAC is associated with excellent prognosis, progression to CAC >0 confers increased risk. The time interval for repeated scanning remains poorly defined.

Methods

This study included 3,116 participants from the MESA (Multi-Ethnic Study of Atherosclerosis) with baseline CAC = 0 and follow-up scans over 10 years after baseline. Prevalence of incident CAC, defined by thresholds of CAC >0, CAC >10, or CAC >100, was calculated and time to progression was derived from a Weibull parametric survival model. Warranty periods were modeled as a function of sex, race/ethnicity, cardiovascular risk, and desired yield

SUBMITTER: Dzaye O 

PROVIDER: S-EPMC8076346 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature