Ocular Health of Octodon degus as a Clinical Marker for Age-Related and Age-Independent Neurodegeneration.

ABSTRACT: The aging process and age-related diseases such as Alzheimer's disease (AD), are very heterogeneous and multifactorial, making it challenging to diagnose the disease based solely on genetic, behavioral tests, or clinical history. It is yet to be explained what ophthalmological tests relate specifically to aging and AD. To this end, we have selected the common degu (Octodon degus) as a model for aging which develops AD-like signs to conduct ophthalmological screening methods that could be clinical markers of aging and AD. We investigated ocular health using ophthalmoscopy, fundus photography, intraocular pressure (IOP), and pupillary light reflex (PLR). The results showed significant presence of cataracts in adult degus and IOP was also found to increase significantly with advancing

SUBMITTER: Chang LY 

PROVIDER: S-EPMC8076605 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature