Anticardiolipin and other antiphospholipid antibodies in critically ill COVID-19 positive and negative patients.

ABSTRACT:

Background

Reports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and antiphospholipid syndrome have yielded disparate conclusions. Studies comparing patients with COVID-19 with contemporaneous controls of similar severity are lacking.

Methods

22 COVID-19⁺ and 20 COVID-19^- patients with respiratory failure admitted to intensive care were studied longitudinally. Demographic and clinical data were obtained from the day of admission. APLA testing included anticardiolipin (aCL), anti-β2glycoprotien 1 (β2GP1), antidomain 1 β2GP1 and antiphosphatidyl serine/prothrombin complex. Antinuclear antibodies (ANAs) were detected by immunofluorescence and antibodies to cytokines by a commercially available multiplexed array. A

SUBMITTER: Trahtemberg U 

PROVIDER: S-EPMC8076626 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature