Optimal allocation of limited vaccine to control an infectious disease: Simple analytical conditions.

ABSTRACT: When allocating limited vaccines to control an infectious disease, policy makers frequently have goals relating to individual health benefits (e.g., reduced morbidity and mortality) as well as population-level health benefits (e.g., reduced transmission and possible disease eradication). We consider the optimal allocation of a limited supply of a preventive vaccine to control an infectious disease, and four different allocation objectives: minimize new infections, deaths, life years lost, or quality-adjusted life years (QALYs) lost due to death. We consider an SIR model with n interacting populations, and a single allocation of vaccine at time 0. We approximate the model dynamics to develop simple analytical conditions characterizing the optimal vaccine allocation for each objective. We in

SUBMITTER: Rao IJ 

PROVIDER: S-EPMC8076816 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature