Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD.

ABSTRACT:

Background

Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study has investigate the association between sRAGE and emphysema. No cohorts have examined the association between sRAGE and progressive decline of lung function. There have also been no evaluation of assay compatibility, receiver operating characteristics, and little examination of the effect of genetic variability in non-white population. This manuscript addresses these deficiencies and introduces novel data from Pittsburgh COPD SCCOR and as well as novel work on airflow obstruction. A meta-analysis is used to quantify sRAGE associations with clinical phenotypes.

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SUBMITTER: Pratte KA 

PROVIDER: S-EPMC8076883 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature