Ecto-5'-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells.

ABSTRACT: Ecto-5'-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is being investigated as a target for new antitumor therapies. We and others have described that CD73 is present at the surface of different CD8+ T cell subsets. Nonetheless, there is limited information as to whether CD73 affects CD8+ T cell proliferation and survival. In this study, we assessed the impact of CD73 deficiency on CD8+ T cells by analyzing their proliferation and survival in antigenic and homeostatic conditions. Results obtained from adoptive transfer experiments demonstrate a paradoxical role of CD73. On one side, it favors the expression of interleukin-7 recep

SUBMITTER: Rosemblatt MV 

PROVIDER: S-EPMC8076893 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature