Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing.

ABSTRACT:

Importance

Myelin oligodendrocyte glycoprotein-IgG1-associated disorder (MOGAD) is a distinct central nervous system-demyelinating disease. Positive results on MOG-IgG1 testing by live cell-based assays can confirm a MOGAD diagnosis, but false-positive results may occur.

Objective

To determine the positive predictive value (PPV) of MOG-IgG1 testing in a tertiary referral center.

Design, setting, and participants

This diagnostic study was conducted over 2 years, from January 1, 2018, through December 31, 2019. Patients in the Mayo Clinic who were consecutively tested for MOG-IgG1 by live cell-based flow cytometry during their diagnostic workup were included. Patients without research authorization were excluded.

Main outcomes and measures

Medical records of pati

SUBMITTER: Sechi E 

PROVIDER: S-EPMC8077043 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature