Effect of Varenicline on Tardive Dyskinesia: A Pilot Study.

ABSTRACT:

Objective

Although evidence implicates striatal cholinergic impairment as a mechanism underlying tardive dyskinesia, trials of nonspecific cholinergic agents have been inconclusive. As a partial agonist at specific nicotinic receptor subtypes, varenicline reduces drug-induced dyskinesias in animal models suggesting promise as a treatment for tardive dyskinesia.

Methods

Three schizophrenia patients with tardive dyskinesia who were smokers underwent an open trial of varenicline. After a 2-week baseline, subjects received varenicline 1 mg twice daily. Changes from baseline on the Abnormal Involuntary Movement Scale were measured after a 4-week varenicline stabilization period, and 6 weeks after the smoking quit date in one patient.

Results

Varenicline had no effect on me

SUBMITTER: Caroff SN 

PROVIDER: S-EPMC8077061 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature