Combining bioinformatics analysis and experiments to explore CARNS1 as a prognostic biomarker for breast cancer.

ABSTRACT:

Background

Breast cancer is a heterogeneous malignant disease, which has variation in clinical behaviors. High-throughput technologies have added important genetic alternative and biological change information for breast cancer. CARNS1 is an important ATPases. It can catalyze the synthesis of carnosine, which has antiproliferative activity in cancer. Here, we hypothesize that CARNS1 plays an essential role in the development of breast cancer.

Methods

The expressions of CARNS1 in breast cancer were data-mined and analyzed from TCGA (the Cancer Genome Atlas) and GEO (the Gene Expression Omnibus) databases. The correlation of CARNS1 expression with clinical characteristics and the diagnostic capability of CARNS1 were assessed. Experimental studies were conducted in two cohorts

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8077083 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature