Maternal adiposity is associated with inflammatory gene expression in leukocytes at term human pregnancy: A pilot study.

ABSTRACT:

Background

Human labor is associated with an inflammatory process that takes place at the maternal-fetal interface, where leukocytes infiltrate and contribute to the local production of effector molecules such as cytokines, chemokines, MMPs, etc. This process may be altered by a low-grade chronic inflammation, characteristic of obesity, resulting in adverse pregnancy outcomes. In this cross-sectional pilot study, we analyzed the relationship between maternal adiposity and inflammation-related gene expression in leukocytes from six healthy women with term pregnancies without labor.

Methods

We estimated maternal adiposity and examined the relative expression of 211 inflammation-related genes in maternal peripheral blood leukocytes (MAT), placental intervillous blood leukocytes

SUBMITTER: MacDonald-Ramos K 

PROVIDER: S-EPMC8077112 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature