Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene.

ABSTRACT:

Purpose

To evaluate the influence of single nucleotide polymorphisms (SNPs) of CYP19A1 on the response and susceptibility to side effects from testosterone therapy. This is a prospective, single-arm study of men with low-morning serum testosterone (<10.68 nmol/l) administered testosterone cypionate 200 mg intramuscularly every 2 weeks for 18 months.

Methods

We measured areal bone mineral density (aBMD) and body composition by dual energy X-ray absorptiometry, tibial volumetric BMD and geometry by peripheral quantitative computer tomography, bone turnover markers by enzyme-linked immunosorbent assay, testosterone, and estradiol by liquid-chromatography/mass-spectroscopy, genotyping by microarray, CYP19A1 expression by quantitative polymerase chain reaction, hematocrit and pro

SUBMITTER: Aguirre LE 

PROVIDER: S-EPMC8077393 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature