Ontology highlight
ABSTRACT:
SUBMITTER: Assumpcao ALFV
PROVIDER: S-EPMC8077518 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Assumpção Anna L F V ALFV Fu Guoping G Singh Deependra K DK Lu Zhanping Z Kuehnl Ashley M AM Welch Rene R Ong Irene M IM Wen Renren R Pan Xuan X
Development (Cambridge, England) 20210415 7
Yin Yang 1 (YY1) is a ubiquitous transcription factor and mammalian Polycomb Group protein (PcG) with important functions for regulating lymphocyte development and stem cell self-renewal. YY1 mediates stable PcG-dependent transcriptional repression via recruitment of PcG proteins that result in histone modifications. Many questions remain unanswered regarding how cell- and tissue-specificity is achieved by PcG proteins. Here, we demonstrate that a conditional knockout of Yy1 in the hematopoietic ...[more]