Functional Testing for Tranexamic Acid Duration of Action Using Modified Viscoelastometry.

ABSTRACT:

Introduction

Tranexamic acid (TXA) is the standard medication to prevent or treat hyperfibrinolysis. However, prolonged inhibition of lysis (so-called "fibrinolytic shutdown") correlates with increased mortality. A new viscoelastometric test enables bedside quantification of the antifibrinolytic activity of TXA using tissue plasminogen activator (TPA).

Materials and methods

Twenty-five cardiac surgery patients were included in this prospective observational study. In vivo, the viscoelastometric TPA test was used to determine lysis time (LT) and maximum lysis (ML) over 96 h after TXA bolus. Additionally, plasma concentrations of TXA and plasminogen activator inhibitor 1 (PAI-1) were measured. Moreover, dose effect curves from the blood of healthy volunteers were performed in

SUBMITTER: Kammerer T 

PROVIDER: S-EPMC8077595 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature