Thyroid Hormones within the Normal Range and Cardiac Function in the General Population: The EPIPorto Study.

ABSTRACT:

Background

Hypothyroidism and hyperthyroidism are associated with marked changes in cardiac structure and function. However, the association of thyroid function within the normal range with cardiac structure and function in the general population remains uncertain.

Methods

Eight hundred thirty-five subjects aged ≥45 years from the EPIPorto cohort (evaluation between 2006 and 2008) were cross-sectionally analyzed. We excluded participants with TSH, free T4 (FT4), or free T3 (FT3) outside of the reference range or with self-reported cardiovascular or thyroid disease. Cardiac structure and function were evaluated by echocardiography. We used linear regression models unadjusted and adjusted for sex and age (model 1), and sex, age, BMI, diabetes, hypertension, and smoking (model

SUBMITTER: Neves JS 

PROVIDER: S-EPMC8077596 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature