Kidney age - chronological age difference (KCD) score provides an age-adapted measure of kidney function.

ABSTRACT:

Background

Given the age-related decline in glomerular filtration rate (GFR) in healthy individuals, we examined the association of all-cause death or cardiovascular event with the Kidney age - Chronological age Difference (KCD) score, whereby an individual's kidney age is estimated from their estimated GFR (eGFR) and the age-dependent eGFR decline reported for healthy living potential kidney donors.

Methods

We examined the association between death or cardiovascular event and KCD score, age-dependent stepped eGFR criteria (eGFRstep), and eGFR < 60 ml/min/1.73 m² (eGFR60) in a community-based high cardiovascular risk cohort of 3837 individuals aged ≥60 (median 70, interquartile range 65, 75) years, followed for a median of 5.6 years.

Results

In proportional

SUBMITTER: Campbell DJ 

PROVIDER: S-EPMC8077774 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature