Evaluation of 32 rapid tests for detection of antibodies against SARS-CoV-2.

ABSTRACT:

Aims

To evaluate the analytical performance of 32 rapid tests for detection of antibodies against coronavirus SARS-CoV-2.

Materials and methods

We used at total of 262 serum samples (197 pre-pandemic and 65 convalescent COVID-19), and three criteria to evaluate the rapid tests under standardized and optimal conditions: (i) Immunoglobulin G (IgG) specificity "good" if lower limit of the 95% confidence interval was ≥ 97.0%, "acceptable" if point estimate was ≥ 97.0%, otherwise "not acceptable". (ii) IgG sensitivity "good" if point estimate was ≥ 90.0%, "acceptable" if ≥ 85.0%, otherwise "not acceptable". (iii) User-friendliness "not acceptable" if complicated to perform or difficult to read result, otherwise "good". We also included partial evaluations of three automated immun

SUBMITTER: Tollanes MC 

PROVIDER: S-EPMC8078036 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature