Pharmacological treatment for continuous spike-wave during slow wave sleep syndrome and Landau-Kleffner Syndrome.

ABSTRACT:

Background

Continuous spike-wave during slow wave sleep syndrome (CSWS) and Landau-Kleffner syndrome (LKS) are two epileptic encephalopathies that present with neurocognitive regression, aphasia, and clinical seizures, typically presenting in children around five years of age. The pathophysiology of these conditions is not completely understood. Some studies suggest a common origin for both. No systematic reviews have assessed the efficacy of pharmacological interventions for these conditions.

Objectives

To assess the benefit and adverse effects of pharmacological interventions for the treatment of CSWS and LKS.

Search methods

On 8 September 2020, we searched the Cochrane Register of Studies (CRS Web) and MEDLINE Ovid (1946 to September 04, 2020). We applied no langua

SUBMITTER: Moresco L 

PROVIDER: S-EPMC8078191 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature