Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma.

ABSTRACT:

Purpose

We sought to investigate clinical outcomes of relapsed medulloblastoma and to compare molecular features between patient-matched diagnostic and relapsed tumors.

Methods

Children and infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00602667) trials who experienced medulloblastoma relapse were analyzed for clinical outcomes, including anatomic and temporal patterns of relapse and postrelapse survival. A largely independent, paired molecular cohort was analyzed by DNA methylation array and next-generation sequencing.

Results

A total of 72 of 329 (22%) SJMB03 and 52 of 79 (66%) SJYC07 patients experienced relapse with significant representation of Group 3 and wingless tumors. Although most patients exhibited some distal disease (79%), 38% of patients

SUBMITTER: Kumar R 

PROVIDER: S-EPMC8078396 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature