Accuracy for Mortality Prediction With Additive Biomarkers Including Interleukin-6 in Critically Ill Patients: A Multicenter Prospective Observational Study.

ABSTRACT:

Objectives

Several inflammation markers have been reported to be associated with unfavorable clinical outcomes in critically ill patients. We aimed to elucidate whether serum interleukin-6 concentration considered with Sequential Organ Failure Assessment score can better predict mortality in critically ill patients.

Design

A prospective observational study.

Setting

Five university hospitals in 2016-2018.

Patients

Critically ill adult patients who met greater than or equal to two systemic inflammatory response syndrome criteria at admission were included, and those who died or were discharged within 48 hours were excluded.

Interventions

Inflammatory biomarkers including interleukin (interleukin)-6, -8, and -10; tumor necrosis factor-α; C-reactive protein;

SUBMITTER: Yamamoto R 

PROVIDER: S-EPMC8078448 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature