Genistein as a dietary supplement; formulation, analysis and pharmacokinetics study.

ABSTRACT: The objective of this study is to improve and optimize the formulation of Genistein in capsules in order to result in a better pharmacokinetic profile comparing to existing commercial products. In order to do this, five different formulations of Genistein capsules were developed and examined by reviewing their disintegration and dissolution properties. Furthermore, flowability of the powder along with potent incompatibilities between Genistein and its excipients were monitored through their thermal properties. The final formulation of Genistein was quantified using HPLC analysis and then its stability was evaluated thoroughly in real time and accelerated conditions. Finally, with the target to have a product with actual results, in vitro and in vivo studies were conducted. The final produc

SUBMITTER: Mamagkaki A 

PROVIDER: S-EPMC8078810 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature