Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage.

ABSTRACT: During episodes of acute inflammation, polymorphonuclear leukocytes (PMNs) are actively recruited to sites of inflammation or injury where they provide anti-microbial and wound-healing functions. One enzyme crucial for fulfilling these functions is myeloperoxidase (MPO), which generates hypochlorous acid from Cl^- and hydrogen peroxide. The potential exists, however, that uncontrolled the extracellular generation of hypochlorous acid by MPO can cause bystander tissue damage and inhibit the healing response. Previous work suggests that the microbiota-derived tryptophan metabolites 1H-indole and related molecules ("indoles") are protective during intestinal inflammation, although their precise mechanism of action is unclear. In the present work, we serendipitously discovered that i

SUBMITTER: Alexeev EE 

PROVIDER: S-EPMC8078834 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature